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2026 NFL · market snapshot Oct 10, 2026, 8:27 PM EDT

NFL Week 6 Picks and Predictions.

San Francisco 49ers carries the strongest straight-up model probability on the slate. Every number below is tied to the displayed market snapshot and a pregame model run.

Games on the slate
14
2025 straight up
60.1%
2025 ATS
81–82
2025 totals
81–80
AwaySeahawks
AT
HomeBroncos
Thursday · Oct 15 · 8:15 PM ET

Denver Broncos 21–22

Win pick
Broncos 53%
ATS lean
DEN +1.5
Total lean
Over 42.5

Market: SEA -122 · DEN +102 · total 42.5

Full game file →
AwayTexans
AT
HomeJaguars
Sunday · Oct 18 · 9:30 AM ET

Jacksonville Jaguars 16–28

Win pick
Jaguars 81%
ATS lean
JAX -3
Total lean
Pass

Market: HOU +145 · JAX -175 · total 43.5

Full game file →
AwayBears
AT
HomeFalcons
Sunday · Oct 18 · 1:00 PM ET

Chicago Bears 25–21

Win pick
Bears 61%
ATS lean
CHI -1.5
Total lean
Under 47.5

Market: CHI -122 · ATL +102 · total 47.5

Full game file →
AwayRavens
AT
HomeBrowns
Sunday · Oct 18 · 1:00 PM ET

Baltimore Ravens 24–23

Win pick
Ravens 51%
ATS lean
CLE +3
Total lean
Over 41.5

Market: BAL -166 · CLE +140 · total 41.5

Full game file →
AwayPanthers
AT
HomeEagles
Sunday · Oct 18 · 1:00 PM ET

Carolina Panthers 23–22

Win pick
Panthers 51%
ATS lean
CAR +2.5
Total lean
Over 43.5

Market: CAR +110 · PHI -130 · total 43.5

Full game file →
AwayTitans
AT
HomeColts
Sunday · Oct 18 · 1:00 PM ET

Indianapolis Colts 16–29

Win pick
Colts 84%
ATS lean
IND -6.5
Total lean
Over 44.5

Market: TEN +235 · IND -290 · total 44.5

Full game file →
AwayJets
AT
HomePatriots
Sunday · Oct 18 · 1:00 PM ET

New England Patriots 14–29

Win pick
Patriots 88%
ATS lean
NE -7
Total lean
Pass

Market: NYJ +260 · NE -325 · total 43.5

Full game file →
AwaySaints
AT
HomeGiants
Sunday · Oct 18 · 1:00 PM ET

New York Giants 22–25

Win pick
Giants 58%
ATS lean
NYG +1.5
Total lean
Over 45.5

Market: NO -118 · NYG -102 · total 45.5

Full game file →
AwaySteelers
AT
HomeBuccaneers
Sunday · Oct 18 · 1:00 PM ET

Pittsburgh Steelers 23–22

Win pick
Steelers 51%
ATS lean
TB +2.5
Total lean
Over 39.5

Market: PIT -134 · TB +114 · total 39.5

Full game file →
AwayCardinals
AT
HomeRams
Sunday · Oct 18 · 4:05 PM ET

Los Angeles Rams 16–32

Win pick
Rams 88%
ATS lean
LAR -10.5
Total lean
Under 51.5

Market: ARI +470 · LAR -650 · total 51.5

Full game file →
AwayBills
AT
HomeRaiders
Sunday · Oct 18 · 4:25 PM ET

Buffalo Bills 27–22

Win pick
Bills 66%
ATS lean
BUF -4.5
Total lean
Under 51.5

Market: BUF -230 · LV +190 · total 51.5

Full game file →
AwayChargers
AT
HomeChiefs
Sunday · Oct 18 · 4:25 PM ET

Kansas City Chiefs 16–27

Win pick
Chiefs 80%
ATS lean
KC -7.5
Total lean
Under 45.5

Market: LAC +310 · KC -395 · total 45.5

Full game file →
AwayCowboys
AT
HomePackers
Sunday · Oct 18 · 8:20 PM ET

Green Bay Packers 23–27

Win pick
Packers 62%
ATS lean
GB +1.5
Total lean
Pass

Market: DAL -126 · GB +108 · total 50.5

Full game file →
AwayCommanders
AT
Home49ers
Monday · Oct 19 · 8:15 PM ET

San Francisco 49ers 16–33

Win pick
49ers 90%
ATS lean
SF -7.5
Total lean
Under 50.5

Market: WAS +330 · SF -425 · total 50.5

Full game file →
Read the number

A model difference, not a promise.

FTT blends opponent-adjusted scoring margin, recent scoring, prior-season strength, site and rest. The market line is a separate input used only to calculate the displayed difference.

The same rules went 125–83 straight up, 81–82 ATS and 81–80 on totals across 208 games in the 2025 Weeks 5-18 walk-forward. The ATS and totals records were effectively coin flips; the displayed differences are research signals, not a proven wagering edge.

See the complete methodology →
Questions, answered

What are the best NFL Week 6 predictions?

The page ranks the current model differences and shows the evidence for every game. A larger difference is a stronger model signal, not a guaranteed result.

Where do the odds and lines come from?

FTT reads the nflverse schedule release, stores the market snapshot time, and freezes each pregame record at kickoff. It does not scrape or name an individual sportsbook.

How does the FTT NFL model work?

The model blends opponent-adjusted scoring margin, recent points scored and allowed, prior-season strength, home field and rest. Market lines are shown for comparison, not used to create the team rating.

Do the picks update after kickoff?

No. Pregame projections and the attached line snapshot freeze at kickoff. Final scores then grade the archived call without rewriting it.