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NFL Week 5 · Sunday, Oct 11 · 4:25 PM ET

49ers vs. Seahawks prediction.

Seattle Seahawks is the FTT straight-up pick at 51% model probability. The projected score is SF 23, SEA 24.

Market snapshot: Oct 10, 2026, 8:27 PM EDT. Pregame numbers freeze at kickoff and do not move after the result.

Away

San Francisco 49ers

23
Record
4-0
FTT rating
+7.4
Listed QB
Purdy
Home

Seattle Seahawks

24
Record
3-1
FTT rating
+6.4
Listed QB
Lock
Model vs. market

The pick, spread and total in one view.

MarketListed numberFTT numberFTT leanDifference
WinnerSEA 59% marketSEA 51% modelSeattle Seahawks -1628.0 points
SpreadSEA -3SEA -0.5San Francisco 49ers +32.5 points
TotalO/U 45.546.0Pass0.5 points
Why the model landed here

Strength, scoring, site and rest.

San Francisco 49ers entered Week 5 at 4-0 with a +14.5 point differential per game. Seattle Seahawks entered at 3-1 and +8.0 per game.

Seattle Seahawks receives the model's 1.5-point home-field adjustment. The rest difference is even.

The scoring projection regresses both teams' current points scored and allowed toward their prior-season baselines. The opponent-adjusted rating caps individual game margins at 28 points so one blowout cannot dominate the board.

On the 2025 Weeks 5-18 walk-forward, these rules finished 125–83 straight up, 81–82 ATS and 81–80 on totals. The ATS and totals results were effectively coin flips.

Full slateWeek 5 predictions →Spread boardAll ATS differences →Totals boardAll over / unders →
Questions, answered

Who will win 49ers vs. Seahawks?

The FTT model picks Seattle Seahawks. Its projected score is SF 23, SEA 24.

What is the 49ers vs. Seahawks spread pick?

The model leans San Francisco 49ers +3, with a 2.5-point difference from the listed spread.

What is the 49ers vs. Seahawks over/under pick?

The model difference is under one point, so FTT passes on the 45.5 total.

When were these odds captured?

The market snapshot was captured Oct 10, 2026, 8:27 PM EDT. Odds can move, and FTT does not present the snapshot as a live sportsbook quote.