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NFL Week 5 · Monday, Oct 12 · 8:15 PM ET

Bills vs. Rams prediction.

Los Angeles Rams is the FTT straight-up pick at 64% model probability. The projected score is BUF 23, LAR 28.

Market snapshot: Oct 10, 2026, 8:27 PM EDT. Pregame numbers freeze at kickoff and do not move after the result.

Away

Buffalo Bills

23
Record
3-1
FTT rating
+3.6
Listed QB
Allen
Home

Los Angeles Rams

28
Record
2-2
FTT rating
+7.0
Listed QB
Stafford
Model vs. market

The pick, spread and total in one view.

MarketListed numberFTT numberFTT leanDifference
WinnerLAR 62% marketLAR 64% modelLos Angeles Rams -1802.5 points
SpreadLAR -3.5LAR -4.9Los Angeles Rams -3.51.4 points
TotalO/U 54.550.3Under 54.54.2 points
Why the model landed here

Strength, scoring, site and rest.

Buffalo Bills entered Week 5 at 3-1 with a +5.0 point differential per game. Los Angeles Rams entered at 2-2 and +0.5 per game.

Los Angeles Rams receives the model's 1.5-point home-field adjustment. The rest difference is even.

The scoring projection regresses both teams' current points scored and allowed toward their prior-season baselines. The opponent-adjusted rating caps individual game margins at 28 points so one blowout cannot dominate the board.

On the 2025 Weeks 5-18 walk-forward, these rules finished 125–83 straight up, 81–82 ATS and 81–80 on totals. The ATS and totals results were effectively coin flips.

Full slateWeek 5 predictions →Spread boardAll ATS differences →Totals boardAll over / unders →
Questions, answered

Who will win Bills vs. Rams?

The FTT model picks Los Angeles Rams. Its projected score is BUF 23, LAR 28.

What is the Bills vs. Rams spread pick?

The model leans Los Angeles Rams -3.5, with a 1.4-point difference from the listed spread.

What is the Bills vs. Rams over/under pick?

The model leans under 54.5, with a 4.2-point difference.

When were these odds captured?

The market snapshot was captured Oct 10, 2026, 8:27 PM EDT. Odds can move, and FTT does not present the snapshot as a live sportsbook quote.