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NFL Week 11 · Sunday, Nov 22 · 8:20 PM ET

Vikings vs. 49ers prediction.

San Francisco 49ers is the FTT straight-up pick at 62% model probability. The projected score is MIN 19, SF 23.

Market snapshot: Nov 14, 2026, 8:01 PM EST. Pregame numbers freeze at kickoff and do not move after the result.

Away

Minnesota Vikings

19
Record
6-2
FTT rating
+1.5
Listed QB
Cousins
Home

San Francisco 49ers

23
Record
7-1
FTT rating
+5.6
Listed QB
Purdy
Model vs. market

The pick, spread and total in one view.

MarketListed numberFTT numberFTT leanDifference
WinnerSF 64% marketSF 62% modelSan Francisco 49ers -2052.4 points
SpreadSF -3.5SF -4.1Pass0.6 points
TotalO/U 45.541.6Under 45.53.9 points
Why the model landed here

Strength, scoring, site and rest.

Minnesota Vikings entered Week 11 at 6-2 with a +3.8 point differential per game. San Francisco 49ers entered at 7-1 and +9.9 per game.

The game is at a neutral site. The rest difference is even.

The scoring projection regresses both teams' current points scored and allowed toward their prior-season baselines. The opponent-adjusted rating caps individual game margins at 28 points so one blowout cannot dominate the board.

On the 2025 Weeks 5-18 walk-forward, these rules finished 125–83 straight up, 81–82 ATS and 81–80 on totals. The ATS and totals results were effectively coin flips.

Full slateWeek 11 predictions →Spread boardAll ATS differences →Totals boardAll over / unders →
Questions, answered

Who will win Vikings vs. 49ers?

The FTT model picks San Francisco 49ers. Its projected score is MIN 19, SF 23.

What is the Vikings vs. 49ers spread pick?

The model difference is under one point, so FTT passes at -3.5.

What is the Vikings vs. 49ers over/under pick?

The model leans under 45.5, with a 3.9-point difference.

When were these odds captured?

The market snapshot was captured Nov 14, 2026, 8:01 PM EST. Odds can move, and FTT does not present the snapshot as a live sportsbook quote.